Obesity Discussion Forums

[Obesity Discussion]

Syndromic Obesity and Diabetes: Changes in Body Composition with Age and Mutation Analysis of ALMS1 in 12 United Kingdom Kindreds with Alström Syndrome
J. A. L. Minton1, K. R. Owen1, C. J. Ricketts1, N. Crabtree, G. Shaikh, S. Ehtisham, J. R. Porter, C. Carey, D. Hodge, R. Paisey, M. Walker and T. G. Barrett
Medical and Molecular Genetics (J.A.L.M., C.J.R., T.G.B.), Birmingham University, Birmingham B15 2TT, United Kingdom; Diabetes Research Laboratories (K.R.O.), University of Oxford, Oxford OX3 7LJ, United Kingdom; Department of Endocrinology (N.C., G.S., S.E., J.R.P.), Birmingham Children’s Hospital, Birmingham B4 6NH, United Kingdom; Department of Medicine (C.C., D.H., R.P.), Torbay District General Hospital, Torquay TQ2 7AA, United Kingdom; and Department of Molecular Medicine (M.W.), Biomedical Sciences, University of Newcastle, Newcastle NE2 4HH, United Kingdom

Address all correspondence and requests for reprints to: Dr. Timothy Barrett, Medical and Molecular Genetics, Institute for Biomedical Research, The Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom. E-mail: t.g.barrett@bham.ac.uk.

Context: Alström syndrome (AS) is a monogenic form of infancy-onset obesity and insulin resistance, caused by ALMS1 mutations. The natural history of the insulin resistance is unknown, in particular how this relates to changes in body composition. It is also unclear how ALMS1 mutations relate to the characteristic phenotype.

Objectives: Our objectives were to characterize body composition and metabolic parameters, to establish ALMS1 mutation spectrum of United Kingdom AS patients, and to determine whether a genotype-phenotype correlation exists.

Design and Patients: We conducted a cross-sectional cohort study of 12 unrelated subjects with AS. Age-standardized body composition was assessed by anthropometry and dual-energy x-ray absorptiometry and insulin sensitivity by homeostasis model assessment. The exons and intron-exon boundaries of ALMS1 were directly sequenced.

Setting: The study was performed during the annual Alström Syndrome UK multidisciplinary screening clinic.

Results: AS patients have early-onset obesity, but body mass index, waist circumference, and body fat from dual-energy x-ray absorptiometry were negatively correlated with age (r = –0.37, P = 0.2; r = –0.84, P = 0.002; and r = –0.6, P = 0.05). Despite this, insulin resistance increased, demonstrated by raised fasting insulin and fall in homeostasis model assessment insulin sensitivity with age (r = –0.64, P = 0.02). ALMS1 mutations were identified in 10 of 12 patients, with a potential founder mutation in exon 16 present in five [np 10775del (C); Del3592fs/ter3597]. No genotype-phenotype correlation was observed.

Conclusions: We identified mutations in ALMS1 in more than 80% of patients with no genotype-phenotype correlation. In AS, severe childhood obesity, waist circumference, and body fat decrease with age, whereas insulin resistance increases. The abdominal obesity, insulin resistance, diabetes, hypertriglyceridemia, and hypertension suggest that AS could represent a monogenic model for the metabolic syndrome.

Article

[yuliyasha]

The genetic predisposition to Diabetes and/or Obesity is caused by mutations of many genes. There's at least 4-5 of them I can remember...It's a very complex relationship which cannot be easily identified, meaning that mutations might not be evident until the person reaches certain age...i.e. majority of people are asymptomatic to diabetes until age 40. Statistically, diabetes mellitus II becomes symptomatic at the geriatric population (>65 y.o.)...as an article said, resistance to insulin increases with age, and compensatory mechanisms cannot control sugar levels by diet alone.
So, genetic and environmental factors affect results at the end. If the person didn't have a healthy lifestyle (well-balances diet and exercise), he or she is definitely more prone to reveal symptoms of diabetes earlier in life. AND alterations in metabolism, such as obesity, act as a trigger to accelerate disruptions in homeostasis.

[Irving]

Originally Posted by yuliyasha

The genetic predisposition to Diabetes and/or Obesity is caused by mutations of many genes. There's at least 4-5 of them I can remember...It's a very complex relationship which cannot be easily identified, meaning that mutations might not be evident until the person reaches certain age...i.e. majority of people are asymptomatic to diabetes until age 40. Statistically, diabetes mellitus II becomes symptomatic at the geriatric population (>65 y.o.)...as an article said, resistance to insulin increases with age, and compensatory mechanisms cannot control sugar levels by diet alone.
So, genetic and environmental factors affect results at the end. If the person didn't have a healthy lifestyle (well-balances diet and exercise), he or she is definitely more prone to reveal symptoms of diabetes earlier in life. AND alterations in metabolism, such as obesity, act as a trigger to accelerate disruptions in homeostasis.

Thank you for translating that into English

[yuliyasha]

you're welcome!!!