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05-21-07, 01:10 PM
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#1 (permalink)
| | Administrator
Join Date: Jan 2005 Location: Phoenix, AZ
Posts: 7,851
Weight Statistics8/1/2006 Start Date:
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| Avandia Heart Attack risk- Diabetes drug gone wrong!
Avandia Heart Attack risk- Diabetes drug gone wrong! May 21, 12:50 PM (ET) By MARILYNN MARCHIONE A new analysis Monday reported the widely prescribed diabetes drug Avandia is linked to a greater risk of heart attack and possibly death. More than 6 million people worldwide have taken the drug sold by London-based GlaxoSmithKline PLC (GSK) since it came on the market eight years ago. Pooled results of dozens of studies revealed a 45 percent higher risk of heart attack, according to the analysis published online by the New England Journal of Medicine.
In a conference call Monday, Glaxo's chief of diabetes drug development, Dr. Lawson McCartney, said the analysis is not definitive scientific proof. The company is not seeing "anything like" the risks reported in the medical journal, he said.
"We remain very confident in the safety and of course in the efficacy of Avandia as an important diabetic medicine," McCartney said.
The U.S. Food and Drug Administration had no immediate comment on Monday's New England Journal report on Avandia.
The company's stock was down 7 percent in morning trading after the medical journal's report appeared.
The report on the risks of the diabetes drug follow Glaxo's $2.5 million settlement of a lawsuit filed by former New York Attorney General Eliot Spitzer over the release of data on the safety and effectiveness of its drugs. Spitzer, now New York governor, accused Glaxo of fraudulently withholding some results of studies that had examined the safety of prescribing the antidepressant Paxil to children.
GlaxoSmithKline disputed that it attempted to mislead anyone, and said it has always been in favor of widespread disclosure of clinical trial results.
Avandia is used to treat Type 2 diabetes, the most common form of the disease, which is linked to obesity. This form of diabetes occurs when the body does not make enough insulin or cannot effectively use what it manages to produce.
Avandia helps sensitize the body to insulin and was considered a breakthrough medication for blood-sugar control. Several experts said Avandia was another Vioxx-like example of the U.S. government failing to detect a safety problem until after millions of people had taken a drug. Vioxx was a blockbuster arthritis medicine until it was withdrawn in 2004 when heart problems came to light.
Avandia Heart Attack
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05-21-07, 11:35 PM
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#2 (permalink)
| | My dream washboard!
Join Date: Mar 2006
Posts: 635
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| Re: Avandia Heart Attack risk- Diabetes drug gone wrong!
I smell another lawsuit!
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06-15-07, 05:26 PM
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#3 (permalink)
| | resident fogey
Join Date: Mar 2006 Location: pittsburgh, pennsylvania
Posts: 693
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| Re: Avandia Heart Attack risk- Diabetes drug gone wrong!
Quote:
Originally Posted by Merle  I smell another lawsuit! |  i swear there is such a rush to get drugs to market that the FDA just approves away before long term tests can be done
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06-24-07, 10:48 PM
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#4 (permalink)
| | BMI is for the BIRDS!
Join Date: Oct 2006 Location: Phoenix
Posts: 957
Weight Statistics10/1/2006 Start Date:
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| Re: Avandia Heart Attack risk- Diabetes drug gone wrong!
My wife takes Avandamet, it looks like it has the same core ingredients as Avandia. Should she be concerned?
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No reason to diet, subscribe to food services, have surgery or take diet pills. Learn to eat right, count calories and exercise. If 400+lb people on Biggest Loser can do it, so can you!
Mike B 6'4" 39 yrs young
**Oct 1 2006 - 310 lbs 40%+ BF ***NEW LOW!!!*** June 8th 2008 - 214.5lbs and dropping!
I had the pain of regret for many years, I now proudly bear the pain of sacrifice.
189lbs LBM last tested Aug 1. 210lbs for 10% BF
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