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Obesity Discussion · 02-13-06, 07:50 PM

Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH).

Authors: Denko, Charles W
Malemud, Charles J.
Source: Rheumatology International; May2006, Vol. 26 Issue 4, p292-297, 6p, 1 chart, 3 graphs

Obesity is a frequent co-morbid condition associated with diffuse idiopathic skeletal hyperostosis (DISH). Serum growth hormone (GH), insulin-like growth factor (IGF-1) and insulin are significantly elevated in patients with DISH. In this study, we examined the relationship between body mass index (BMI) and basal serum GH, IGF-1, and insulin concentration in a group of 36 DISH patients. Basal serum insulin levels were significantly elevated ( P<0.001) in DISH patients with a BMI>28 kg m-2, classified as obese, compared with DISH patients with BMI ranging from 23 to 28 kg m-2. In addition, BMI strongly positively correlated with serum insulin concentration in DISH patients (adjusted r 2=0.348, P<0.001). However, BMI did not correlate with either basal serum GH (adjusted r 2=-0.013) or IGF-1 levels (adjusted r 2=-0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH. [ABSTRACT FROM AUTHOR]

Author Affiliations:
1Departments of Medicine, Division of Rheumatic Diseases, University Hospitals of Cleveland, 2061 Cornell Road, Cleveland, OH 441065076, USA
2Departments of Anatomy, Case Western Reserve University, Cleveland, OH 441065076, USA
3School of Medicine and Case Research Institute, Case Western Reserve University, Cleveland, OH 44106, USA

02-13-06, 07:50 PM	#1 (permalink)
Obesity Discussion Administrator Join Date: Jan 2005 Location: Phoenix, AZ Posts: 7,815 Weight Statistics 8/1/2006 Start Date: 185 lb Start Weight: 152 lb Current Weight: 155 lb Goal Weight: -33 lb Weight Loss: 5/1/2007 Goal Date:	Body mass index and blood glucose: correlations w/ insulin, growth hormone, etc. Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH). Authors: Denko, Charles W Malemud, Charles J. Source: Rheumatology International; May2006, Vol. 26 Issue 4, p292-297, 6p, 1 chart, 3 graphs Obesity is a frequent co-morbid condition associated with diffuse idiopathic skeletal hyperostosis (DISH). Serum growth hormone (GH), insulin-like growth factor (IGF-1) and insulin are significantly elevated in patients with DISH. In this study, we examined the relationship between body mass index (BMI) and basal serum GH, IGF-1, and insulin concentration in a group of 36 DISH patients. Basal serum insulin levels were significantly elevated ( P<0.001) in DISH patients with a BMI>28 kg m<sup>-2</sup>, classified as obese, compared with DISH patients with BMI ranging from 23 to 28 kg m<sup>-2</sup>. In addition, BMI strongly positively correlated with serum insulin concentration in DISH patients (adjusted r <sup>2</sup>=0.348, P<0.001). However, BMI did not correlate with either basal serum GH (adjusted r <sup>2</sup>=-0.013) or IGF-1 levels (adjusted r <sup>2</sup>=-0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH. [ABSTRACT FROM AUTHOR] Author Affiliations: 1Departments of Medicine, Division of Rheumatic Diseases, University Hospitals of Cleveland, 2061 Cornell Road, Cleveland, OH 441065076, USA 2Departments of Anatomy, Case Western Reserve University, Cleveland, OH 441065076, USA 3School of Medicine and Case Research Institute, Case Western Reserve University, Cleveland, OH 44106, USA __________________